alpha smooth muscle Actin Recombinant Rabbit Monoclonal Antibody [SY02-64]
Catalog# ET1607-53
alpha smooth muscle Actin Recombinant Rabbit Monoclonal Antibody [SY02-64]
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WB
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IF-Cell
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IF-Tissue
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IHC-P
-
FC
-
mIHC
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Human
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Mouse
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Rat
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HA750126
不含抗保成分
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unconjugated
製品概要
製品名
alpha smooth muscle Actin Recombinant Rabbit Monoclonal Antibody [SY02-64]
抗体のタイプ
Recombinant Rabbit monoclonal Antibody
免疫原
Synthetic peptide within N-terminal human alpha smooth muscle Actin.
交差反応性（対応種属）
Human, Mouse, Rat
検証済みアプリケーション
WB, IF-Cell, IF-Tissue, IHC-P, FC, mIHC
標的分子量
Predicted band size: 42 kDa
ポジティブコントロール
Saos-2 (Human osteosarcoma cells) cell lysate, A431 (Human epidermoid carcinoma skin squamous cells) cell lysate, NIH/3T3 (Mouse fibroblasts) cell lysate, C2C12 (Mouse myoblasts) cell lysate, Neuro-2a (Mouse brain neuroblastoma cells) cell lysate, Mouse skin tissue lysate, Rat skin tissue lysate.
コンジュゲーション
unconjugated
クローン番号
SY02-64
RRID
Reactivity Data
| WB | IF-Cell | IF-Tissue | IHC-P | FC | mIHC | |
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| Mouse |
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| Rat |
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| Ctenopharyngodon |
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| Rabbit |
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製品の特徴
形態
Liquid
濃度
保存方法
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
保存バッファー
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
アイソタイプ
IgG
精製方法
Protein A affinity purified.
推奨希釈倍率
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WB
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1:1,000-1:5,000
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IF-Cell
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1:2,000-1:5,000
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IF-Tissue
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1:50-1:200
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IHC-P
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1:1,000-1:5,000
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FC
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1:1,000-1:2,000
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mIHC
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1:100-1:500
ターゲット
機能
All eukaryotic cells express Actin, which often constitutes as much as 50% of total cellular protein. Actin filaments can form both stable and labile structures and are crucial components of microvilli and the contractile apparatus of muscle cells. While lower eukaryotes, such as yeast, have only one Actin gene, higher eukaryotes have several isoforms encoded by a family of genes. At least six types of Actin are present in mammalian tissues and fall into three classes. α-Actin expression is limited to various types of muscle, whereas β-Actin and γ-Actin are the principle constituents of filaments in other tissues. Members of the small GTPase family regulate the organization of the Actin cytoskeleton. Rho controls the assembly of Actin stress fibers and focal adhesion. Rac regulates Actin filament accumulation at the plasma membrane. Cdc42 stimulates formation of filopodia.
背景・参考文献
1. Izumi D et al. CXCL12/CXCR4 activation by cancer-associated fibroblasts promotes integrin 1 clustering and invasiveness in gastric cancer. Int J Cancer 138:1207-19 (2016).
2. Chung SI et al. Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background. BMC Gastroenterol 16:13 (2016).
配列相同性
Belongs to the actin family.
翻訳後修飾（PTM）
Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.; Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.; Methylated at His-75 by SETD3.; (Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-52 of one monomer and Glu-272 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding. The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners.
サブセルラー局在
Cytoplasm.
別名
alpha SMA
a-SMA antibody
asma antibody
a actin antibody
AAT6 antibody
ACTA_HUMAN antibody
ACTA2 antibody
Actin alpha 2 smooth muscle aorta antibody
Actin aortic smooth muscle antibody
Actin, aortic smooth muscle antibody
詳細を見る画像
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Application: Immunohistochemistry (IHC-P)
Species: Human
Tissue: Tonsil
Sample: Paraffin-embedded section
Antigen retrieval: Heat-mediated, Tris-EDTA buffer (pH 9.0), 20 minutes at 95℃.
Wash buffer: 1× TBST
Endogenous peroxidase blocking: 3% H₂O₂, 10 minutes at room temperature.
Blocking: 1% BSA + 10% normal goat serum, 10 minutes at room temperature.
Primary antibody: ET1607-53, 1/4,000, 1 hour at room temperature.
Secondary antibody: HA1119, 20 minutes at room temperature. -
Application: Immunohistochemistry (IHC-P)
Species: Human
Tissue: Appendix
Sample: Paraffin-embedded section
Antigen retrieval: Heat-mediated, Tris-EDTA buffer (pH 9.0), 20 minutes at 95℃.
Wash buffer: 1× TBST
Endogenous peroxidase blocking: 3% H₂O₂, 10 minutes at room temperature.
Blocking: 1% BSA + 10% normal goat serum, 10 minutes at room temperature.
Primary antibody: ET1607-53, 1/2,000, 1 hour at room temperature.
Secondary antibody: HA1119, 20 minutes at room temperature. -
Application: Immunohistochemistry (IHC-P)
Species: Human
Tissue: Liver
Sample: Paraffin-embedded section
Antigen retrieval: Heat-mediated, Tris-EDTA buffer (pH 9.0), 20 minutes at 95℃.
Wash buffer: 1× TBST
Endogenous peroxidase blocking: 3% H₂O₂, 10 minutes at room temperature.
Blocking: 1% BSA + 10% normal goat serum, 10 minutes at room temperature.
Primary antibody: ET1607-53, 1/2,000, 1 hour at room temperature.
Secondary antibody: HA1119, 20 minutes at room temperature. -
Application: IF-tissue
Species: Human
Site: Kidney
Sample: Paraffin-embedded section
Antibody concentration: 1/50 -
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Application: IF-tissue
Species: Mouse
Site: Liver
Sample: Paraffin-embedded section
Antibody concentration: 1/50 -
Fluorescence multiplex immunohistochemical analysis of the human pancreatic carcinoma (Formalin/PFA-fixed paraffin-embedded sections). Panel A: the merged image of anti-CD31 (M1511-8, green), anti-α-SMA (ET1607-53, red) and anti-FAP (ET1704-23, yellow) on human pancreatic carcinoma. Panel B: anti- CD31 stained on the endothelial cells. Panel C: anti-α-SMA stained on cancer-associated fibroblasts and smooth muscle cells. Panel D: anti-FAP stained on the cancer-associated fibroblasts. HRP Conjugated UltraPolymer Goat Polyclonal Antibody HA1119/HA1120 was used as a secondary antibody. The immunostaining was performed with the Sequential Immuno-staining Kit (IRISKit™MH010101, www.luminiris.cn). The section was incubated in three rounds of staining: in the order of M1511-8 (1/5000 dilution), ET1704-23 (1/1000 dilution), and ET1607-53 (1/150 dilution) for 20 mins at room temperature. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Nikon ECLIPSE Ni-E microscope.
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Fluorescence multiplex immunohistochemical analysis of Human non-small cell lung cancer (Formalin/PFA-fixed paraffin-embedded sections). Panel A: the merged image of anti-PD-L1 (HA721176, red), anti-CD34 (ET1606-11, green), anti-Pan-CK (HA601138, cyan), anti-CD20 (HA721138, magenta), anti-αSMA (ET1607-53, yellow) and anti-CD57 (HA601114, white) on NSCLC. Panel B: anti-PD-L1 stained on dendritic cells and macrophages cells. Panel C: anti- CD34 stained on endothelial cells. Panel D: anti-Pan-CK stained on cancer cells. Panel E: CD20 stained on B cells. Panel F: anti-αSMA stained on cancer-associated fibroblasts and smooth muscle cells. Panel G: anti-CD57 stained on NK cells and T cells. HRP Conjugated UltraPolymer Goat Polyclonal Antibody HA1119/HA1120 was used as a secondary antibody. The immunostaining was performed with the Sequential Immuno-staining Kit (IRISKit™MH010101, www.luminiris.cn). The section was incubated in six rounds of staining: in the order of HA721176 (1/1,000 dilution), ET1606-11 (1/1,000 dilution), HA601138 (1/3,000 dilution), HA721138 (1/2,000 dilution), ET1607-53 (1/150 dilution) and HA601114 (1/1,000 dilution) for 20 mins at room temperature. Each round was followed by a separate fluorescent tyramide signal amplification system. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
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Fluorescence multiplex immunohistochemical analysis of the human gastric cancer (Formalin/PFA-fixed paraffin-embedded sections). Panel A: the merged image of anti-CD31 (M1511-8, red), anti-αSMA (ET1607-53, gray), anti-CD11b (ET1706-04, cyan), anti-panCK (HA601138, magenta) and anti-CD3 (HA720082, yellow) on human gastric cancer. Panel B: anti- CD31 stained on the endothelial cells. Panel C: anti-αSMA stained on cancer-associated fibroblasts and smooth muscle cells. Panel D: anti-CD11b stained on myeloid cells. Panel E: anti-panCK stained on cancer cells. Panel F: anti-CD3 stained on T cells. HRP Conjugated UltraPolymer Goat Polyclonal Antibody HA1119/HA1120 was used as a secondary antibody. The immunostaining was performed with the Sequential Immuno-staining Kit (IRISKit™MH010101, www.luminiris.cn). The section was incubated in five rounds of staining: in the order of M1511-8 (1/1,000 dilution), ET1607-53 (1/100 dilution), ET1706-04 (1/1,000 dilution), HA601138 (1/3,000 dilution), and HA720082 (1/500 dilution) for 20 mins at room temperature. Each round was followed by a separate fluorescent tyramide signal amplification system. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
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Fluorescence multiplex immunohistochemical analysis of mouse lung (Formalin/PFA-fixed paraffin-embedded sections). Panel A: the merged image of anti-TTF1 (HA720067, Red), anti-RAGE (ET1702-27, Green), anti-aSMA (ET1607-53, Cyan) and anti-Ki67 (HA721115, Yellow) on mouse lung. HRP Conjugated UltraPolymer Goat Polyclonal Antibody HA1119/HA1120 was used as a secondary antibody. The immunostaining was performed with the Sequential Immuno-staining Kit (IRISKit™MH010101, www.luminiris.cn). The section was incubated in four rounds of staining: in the order of HA720067 (1/4,000 dilution), ET1702-27 (1/3,000 dilution), ET1607-53 (1/500 dilution) and HA721115 (1/3,000 dilution) for 20 mins at room temperature. Each round was followed by a separate fluorescent tyramide signal amplification system. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
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Fluorescence multiplex immunohistochemical analysis of human liver (Formalin/PFA-fixed paraffin-embedded sections). Panel A: the merged image of anti-CD31(M1511-8, Red), anti-COL1A1(HA722517, Magenta) and anti-αSMA (ET1607-53, Yellow) on human liver. HRP Conjugated UltraPolymer Goat Polyclonal Antibody HA1119/HA1120 was used as a secondary antibody. The immunostaining was performed with the Sequential Immuno-staining Kit (IRISKit™MH010101, www.luminiris.cn). The section was incubated in three rounds of staining: in the order of M1511-8 (1/1000 dilution), HA722517 (1/10000 dilution) and ET1607-53 (1/250 dilution) for 20 mins at room temperature. Each round was followed by a separate fluorescent tyramide signal amplification system. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95C. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
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Fluorescence multiplex immunohistochemical analysis of mouse pancreas (Formalin/PFA-fixed paraffin-embedded sections). Panel A: the merged image of anti-β-catenin (ET1601-5, Red), anti-Glucagon (ET1702-20, Green), anti-Insulin (ET1601-12, White), anti-CK19 (ET1601-6, Magenta) and anti-aSMA (ET1607-53, Yellow) on mouse pancreas. HRP Conjugated UltraPolymer Goat Polyclonal Antibody HA1119/HA1120 was used as a secondary antibody. The immunostaining was performed with the Sequential Immuno-staining Kit (IRISKit™MH010101, www.luminiris.cn). The section was incubated in five rounds of staining: in the order of ET1601-5 (1/2,000 dilution), ET1702-20 (1/6,000 dilution), ET1601-12 (1/8,000 dilution), ET1601-6 (1/5,000 dilution) and ET1607-53 (1/500 dilution) for 20 mins at room temperature. Each round was followed by a separate fluorescent tyramide signal amplification system. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
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Fluorescence multiplex immunohistochemical analysis of mouse liver (Formalin/PFA-fixed paraffin-embedded sections). Panel A: the merged image of anti-HNF4α (HA721006, Cyan), anti-CK19 (ET1601-6, Magenta) and anti-aSMA (ET1607-53, Yellow) on mouse liver. HRP Conjugated UltraPolymer Goat Polyclonal Antibody HA1119/HA1120 was used as a secondary antibody. The immunostaining was performed with the Sequential Immuno-staining Kit (IRISKit™MH010101, www.luminiris.cn). The section was incubated in three rounds of staining: in the order of HA721006 (1/5,000 dilution), ET1601-6 (1/10,000 dilution) and ET1607-53 (1/500 dilution) for 20 mins at room temperature. Each round was followed by a separate fluorescent tyramide signal amplification system. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
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Fluorescence multiplex immunohistochemical analysis of mouse small intestine (Formalin/PFA-fixed paraffin-embedded sections). Panel A: the merged image of anti-Lysozyme (ET1609-35, Green), anti-villin1 (ET7106-62, Magenta) and anti-aSMA (ET1607-53, Yellow) on mouse small intestine. HRP Conjugated UltraPolymer Goat Polyclonal Antibody HA1119/HA1120 was used as a secondary antibody. The immunostaining was performed with the Sequential Immuno-staining Kit (IRISKit™MH010101, www.luminiris.cn). The section was incubated in three rounds of staining: in the order of ET1609-35 (1/2,000 dilution), ET7106-62 (1/5,000 dilution) and ET1607-53 (1/500 dilution) for 20 mins at room temperature. Each round was followed by a separate fluorescent tyramide signal amplification system. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
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Fluorescence multiplex immunohistochemical analysis of mouse kidney (Formalin/PFA-fixed paraffin-embedded sections). Panel A: the merged image of anti-NPHS2 (ET7107-34, Red), anti-AQP1 (ET1703-34, Green), anti-Laminin beta 1 (ET1703-14, Cyan) and anti-aSMA (ET1607-53, Magenta) on kidney. HRP Conjugated UltraPolymer Goat Polyclonal Antibody HA1119/HA1120 was used as a secondary antibody. The immunostaining was performed with the Sequential Immuno-staining Kit (IRISKit™MH010101, www.luminiris.cn). The section was incubated in four rounds of staining: in the order of ET7107-34 (1/1,000 dilution), ET1703-34 (1/5,000 dilution), ET1703-14 (1/1,000 dilution) and ET1607-53 (1/500 dilution) for 20 mins at room temperature. Each round was followed by a separate fluorescent tyramide signal amplification system. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
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Western blot analysis of alpha smooth muscle Actin on different lysates with Rabbit anti-alpha smooth muscle Actin antibody (ET1607-53) at 1/2,000 dilution.
Lane 1: Saos-2 (Human osteosarcoma cells) cell lysate
Lane 2: A431 (Human epidermoid carcinoma skin squamous cells) cell lysate
Lane 3: NIH/3T3 (Mouse fibroblasts) cell lysate
Lane 4: C2C12 (Mouse myoblasts) cell lysate
Lane 5: Neuro-2a (Mouse brain neuroblastoma cells) cell lysate
Lane 6: Mouse skin tissue lysate
Lane 7: Rat skin tissue lysate
Lysates/proteins at 15 µg/Lane.
Exposure time: 2 seconds; ECL: K1801
Blocking: 5% NFDM/TBST, 1 hour at room temperature
Primary antibody: ET1607-53, 1/2,000 in primary antibody dilution buffer (K1803), overnight at 4 ℃
Secondary antibody: Goat anti-Rabbit IgG-HRP (HA1001), 1/50,000 in 5% NFDM/TBST, 1 hour at room temperature
Predicted band size: 42 kDa
Observed band size: 42 kDa -
Application: Immunocytochemistry (IF-cell)
Species: Human
Sample: Hep G2 (Human liver cancer cells)
Fixation: 4% Paraformaldehyde, 15 minutes at room temperature.
Permeabilization: 0.1% Triton X-100, 15 minutes at room temperature.
Blocking: 1% BSA + 10% normal goat serum, 1 hour at room temperature.
Antibody dilution buffer: 1% BSA in PBST.
Primary antibody: ET1607-53, 1/2,000, overnight at 4℃.
Secondary antibody: Goat Anti-Rabbit IgG (iFluor™ 488, HA1121), 45 minutes at room temperature.
Counterstain: Beta tubulin (HA601187, red), 1/100, overnight at 4℃. The Nuclear counterstain was DAPI (Blue). -
Application: Immunohistochemistry (IHC-P)
Species: Mouse
Tissue: Small intestine
Sample: Paraffin-embedded section
Antigen retrieval: Heat-mediated, Tris-EDTA buffer (pH 9.0), 20 minutes at 95℃.
Wash buffer: 1× TBST
Endogenous peroxidase blocking: 3% H₂O₂, 10 minutes at room temperature.
Blocking: 1% BSA + 10% normal goat serum, 10 minutes at room temperature.
Primary antibody: ET1607-53, 1/1,000, 1 hour at room temperature.
Secondary antibody: HA1119, 20 minutes at room temperature. -
Application: Immunohistochemistry (IHC-P)
Species: Rat
Tissue: Small intestine
Sample: Paraffin-embedded section
Antigen retrieval: Heat-mediated, Tris-EDTA buffer (pH 9.0), 20 minutes at 95℃.
Wash buffer: 1× TBST
Endogenous peroxidase blocking: 3% H₂O₂, 10 minutes at room temperature.
Blocking: 1% BSA + 10% normal goat serum, 10 minutes at room temperature.
Primary antibody: ET1607-53, 1/1,000, 1 hour at room temperature.
Secondary antibody: HA1119, 20 minutes at room temperature. -
Application: Flow Cytometry (Intra)
Species: Human
Sample: Hep G2 (Human liver cancer cells)
Fixation: 4% Paraformaldehyde, 15 minutes at room temperature.
Permeabilization: 1x Permeabilization Buffer (eBioscience), 15 minutes at room temperature.
Blocking: 1% BSA + 10% normal goat serum, 15 minutes at room temperature.
Antibody dilution buffer: 1x PBS.
Primary antibody: ET1607-53 (1/1,000) (Red) compared with Rabbit IgG Isotype Control (HA722127, Green), 15 minutes at room temperature.
Secondary antibody: Goat Anti-Rabbit IgG (iFluor™ 488, HA1121), 15 minutes at room temperature.
ご注意: 本製品はすべて「研究用試薬」です。人や動物の診断・治療目的、または臨床診断には使用できません。（FOR RESEARCH USE ONLY）
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Discovery and validation of a urinary extracellular vesicle protein signature for the diagnosis of renal allograft fibrosis
ジャーナル: Interdisciplinary Medicine
DOI: 10.1002/inmd.70108
IF: 13.6
アプリケーション: WB
交差反応性: Mouse
掲載日: 2026 Mar
-
Apoptotic Vesicle Membrane-Mediated Targeted Endothelial Mitochondrial Transplantation-Clearance Therapy for Diabetic Wound Healing
ジャーナル: Research
DOI: 10.34133/research.1042
IF: 10.7
アプリケーション: IF-tissue
交差反応性: Rat
掲載日: 2026 Jan
-
PTPN2 alleviates Silicotic pulmonary fibrosis by inhibiting senescence of type II alveolar epithelial cells via retinol metabolism regulated by ALDH1A2
ジャーナル: International Immunopharmacology
DOI: 10.1016/j.intimp.2026.116226
IF: 4.7
アプリケーション: WB
交差反応性: Mouse
掲載日: 2026 Jan
-
Suppressing Endothelial–Mesenchymal Transition Through the Histone Deacetylase 1/GATA Binding Protein 4 Pathway: The Mechanism of Protocatechuic Acid Against Myocardial Fibrosis Revealed by an Integrated Study
ジャーナル: Biology-Basel
DOI: 10.3390/biology15020206
IF: 3.5
アプリケーション: IHC
交差反応性: Rat
掲載日: 2026 Jan
-
Macrophage-associated immune-stromal crosstalks correlate with the tumor microenvironment in microsatellite-stable mucinous colorectal cancer
ジャーナル: Pathology Research and Practice
DOI: 10.1016/j.prp.2026.156371
IF: 3.2
アプリケーション: mIF
交差反応性: Human
掲載日: 2026 Jan
-
<p>Natural compound 5,7,8‑trimethoxyflavone mitigates radiation‑induced lung injury by suppressing EMT and PI3K/Akt pathway</p>
ジャーナル: International Journal Of Molecular Medicine
DOI: 10.3892/ijmm.2026.5740
IF: 5.8
アプリケーション: IHC
交差反応性: Mouse
掲載日: 2026 Jan
-
SPP1 Drives Colorectal Cancer Liver Metastasis and Immunotherapy Resistance by Stimulating CXCL12 Production in Cancer-Associated Fibroblasts
ジャーナル: Cancer Research
DOI: 10.1158/0008-5472.CAN-24-4916
IF: 16.6
アプリケーション: IHC,mIF
交差反応性: Human,Mouse
掲載日: 2026 Jan
-
Triptolide Inhibits Renal Fibrosis Through Promotion of PGC1α/PCK1-mediated Renal Gluconeogenesis
ジャーナル: Frontiers In Bioscience-Landmark
DOI: 10.31083/FBL47847
IF: 3.1
アプリケーション: WB
交差反応性: Mouse
掲載日: 2026 Feb
-
Mitofusin 2 Alleviates Liver Fibrogenesis by Suppressing β-Catenin Nuclear Translocation
ジャーナル: Current Medical Science
DOI: 10.1007/s11596-026-00167-y
IF: 1.5
アプリケーション: WB
交差反応性: Mouse
掲載日: 2026 Feb
-
Serpine1 Regulates the Enhanced Inhibitory Effect of CHIR99021 Combined with Fibroblast Growth Factor 2 on Myocardial Fibrosis After Myocardial Infarction in Mice
ジャーナル: International Journal Of Molecular Sciences
DOI: 10.3390/ijms27041627
IF: 4.9
アプリケーション: IF-tissue,WB
交差反応性: Rat
掲載日: 2026 Feb
-
Genipin, A Gut Microbiota-Derived Metabolite of Xihuang Pill, Suppresses Triple-Negative Breast Cancer Angiogenesis by Inhibiting HIF-1α/HSPG2 Axis
ジャーナル: Phytotherapy Research
DOI: 10.1002/ptr.70253
IF: 6.3
アプリケーション: IF-tissue
交差反応性: Mouse
掲載日: 2026 Feb
-
Design, Synthesis, and Biological Evaluation of Arylimidazole Derivatives as Potent PPARδ Agonists for the Treatment of Renal Fibrosis
ジャーナル: Journal Of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.5c03132
IF: 6.8
アプリケーション: WB
交差反応性: Rat,Mouse
掲載日: 2026 Feb
-
SCMO: a deep learning model integrating the single-cell resolution TME ecosystem and multi-omics for survival prediction in CRC patients
ジャーナル: Journal Of Translational Medicine
DOI: 10.1186/s12967-025-07417-y
IF: 7.5
アプリケーション: WB
交差反応性: Human
掲載日: 2026 Feb
-
Berberine inhibits ISG15 and pyroptosis to attenuate diabetic kidney disease inflammation and fibrosis
ジャーナル: Apoptosis
DOI: 10.1007/s10495-026-02282-6
IF: 8.1
アプリケーション: WB
交差反応性: Mouse
掲載日: 2026 Feb
-
Shenkangling alleviates renal fibrosis induced by renal ischemia–reperfusion injury by mitigating mitochondrial damage through modulation of the STING signaling pathway
ジャーナル: Phytomedicine
DOI: 10.1016/j.phymed.2026.158020
IF: 8.3
アプリケーション: WB
交差反応性: Human,Mouse
掲載日: 2026 Feb
-
Aspirin-loaded thermo-sensitive chitosan-sodium alginate hydrogel for the prevention of intrauterine adhesions
ジャーナル: Journal of Biomaterials Science, Polymer Edition
DOI: 10.1080/09205063.2026.2651261
IF: 3.6
アプリケーション: WB
交差反応性: Human,Rat
掲載日: 2026 Apr
-
Enhancer of Zeste Homologue 2 Promotes Vascular Calcification Associated With Chronic Kidney Disease
ジャーナル: Frontiers In Bioscience-Landmark
DOI: 10.31083/FBL48723
IF: 3.1
アプリケーション: WB
交差反応性: Rat
掲載日: 2026 Apr
-
Research on Therapeutic Strategy of Inhalable Cell Membrane-Coated Nanodelivery Complexes Mediating Nrf2 Pathway for Ameliorating Pulmonary Fibrosis
ジャーナル: ACS Applied Materials & Interfaces
DOI: 10.1021/acsami.6c01140
IF: 8.2
アプリケーション: WB
交差反応性: Mouse
掲載日: 2026 Apr
-
Targeting USP4 to inhibit TGF-β signaling: the antifibrotic potential of isovitexin in renal interstitial fibrosis
ジャーナル: Journal of Biomaterials Science, Polymer Edition
DOI: 10.1016/j.phymed.2026.158141
IF: 8.3
アプリケーション: IHC,WB
交差反応性: Mouse,Human,Rat
掲載日: 2026 Apr
-
Ultrasound-targeted microbubble cavitation enhances anti–PD-L1 therapy in TNBC via eNOS-mediated reoxygenation
ジャーナル: Journal Of Clinical Investigation Insight
DOI: 10.1172/jci.insight.198349
IF: 6.1
アプリケーション: mIF
交差反応性: Mouse
掲載日: 2026 Apr
-
Ailanthone ameliorates CCl4-induced liver fibrosis by targeting PKM2-mediated macrophage M1 polarization and glycolytic reprogramming
ジャーナル: International Immunopharmacology
DOI: 10.1016/j.intimp.2026.116640
IF: 4.7
アプリケーション: IHC,WB
交差反応性: Mouse,Human
掲載日: 2026 Apr
-
Deficiency of Vitamin D-binding protein exacerbates liver fibrosis by disrupting iron homeostasis via the activation of YAP signaling
ジャーナル: Experimental Cell Research
DOI: 10.1016/j.yexcr.2025.114767
IF: 3.5
アプリケーション: WB
交差反応性: Mouse
掲載日: 2025 Sept
-
Astragaloside IV Binds with RhoA, Inhibits EndMT and Ameliorates Myocardial Fibrosis in Mice
ジャーナル: American Journal Of Chinese Medicine
DOI: 10.1142/S0192415X25500818
IF: 5.5
アプリケーション: WB
交差反応性: Mouse,Human
掲載日: 2025 Sept
-
Metformin attenuates coal dust nanoparticle-induced pulmonary fibrosis by modulating inflammation and epithelial-mesenchymal transition
ジャーナル: International Immunopharmacology
DOI: 10.1016/j.intimp.2025.115497
IF: 4.7
アプリケーション: WB,IHC
交差反応性: Mouse,Human
掲載日: 2025 Sept
-
Interleukin-17D Attenuates OVA-induced Airway Inflammation and Remodeling Partially via the CD93 Receptor
ジャーナル: Allergy Asthma & Immunology Research
DOI: 10.4168/aair.2025.17.5.592
IF: 4.3
アプリケーション: WB
交差反応性:
掲載日: 2025 Sept
-
MIF Promotes Phenotypic Switching of VSMCs via AKT/mTOR-Mediated Autophagy Regulation in Aortic Dissection
ジャーナル: FASEB Journal
DOI: 10.1096/fj.202501761R
IF: 4.2
アプリケーション: IF-cell
交差反応性: Human
掲載日: 2025 Sept
-
TAT-PBX1 fusion protein alleviates LPS-induced acute lung injury via AMPK-TFAM signaling activation
ジャーナル: Molecular Therapy
DOI: 10.1016/j.ymthe.2025.09.010
IF: 12
アプリケーション: IHC
交差反応性: Mouse
掲載日: 2025 Sept
-
Fennel essential oil and its nanoemulsion modulate macrophage-mediated inflammatory responses and promote pressure ulcer healing
ジャーナル: International Immunopharmacology
DOI: 10.1016/j.intimp.2025.115631
IF: 4.7
アプリケーション: IF-cell
交差反応性: Rat
掲載日: 2025 Oct
-
Brain abundant membrane attached signal protein 1 regulates macrophage polarization through EGFR/PI3K/AKT signaling in renal cell carcinoma
ジャーナル: International Journal Of Biological Macromolecules
DOI: 10.1016/j.ijbiomac.2025.148268
IF: 8.5
アプリケーション: IHC
交差反応性: Mouse
掲載日: 2025 Oct
-
High PEEP Activates ITGB1, Inducing Diaphragm Fibrosis During Prolonged Mechanical Ventilation
ジャーナル: Biomolecules
DOI: 10.3390/biom15101466
IF: 4.8
アプリケーション: WB
交差反応性: Rabbit
掲載日: 2025 Oct
-
Mechanistic study on nonylphenol-induced liver fibrosis via Pink1/Parkin-mediated mitophagy and lipid droplet degradation in hepatic stellate cells
ジャーナル: Ecotoxicology And Environmental Safety
DOI: 10.1016/j.ecoenv.2025.119206
IF: 6.1
アプリケーション: WB,IF-tissue
交差反応性: Mouse,Human
掲載日: 2025 Oct
-
Immune landscape and molecular regulators in renal interstitial fibrosis
ジャーナル: International Immunopharmacology
DOI: 10.1016/j.intimp.2025.115702
IF: 4.7
アプリケーション: WB
交差反応性: Mouse
掲載日: 2025 Oct
-
Ganetespib as an inhibitor of heat shock protein 90 alleviates pulmonary fibrosis by inhibiting the Wnt/β-catenin signaling pathway
ジャーナル: International Immunopharmacology
DOI: 10.1016/j.intimp.2025.115837
IF: 4.7
アプリケーション: WB
交差反応性: Mouse
掲載日: 2025 Nov
-
Genome editing of Spp1 by inhalable CRISPR/Cas9 formulation for treating pulmonary fibrosis
ジャーナル: Journal Of Controlled Release
DOI: 10.1016/j.jconrel.2025.114424
IF: 11.5
アプリケーション:
交差反応性:
掲載日: 2025 Nov
-
Enhanced oral nanomedicine utilizing biomineralized oncolytic virus for synergistic gastrointestinal cancer therapy
ジャーナル: Materials Today Bio
DOI: 10.1016/j.mtbio.2025.102583
IF: 10.2
アプリケーション: WB,IHC
交差反応性: Mouse
掲載日: 2025 Nov
-
Schisandra chinensis-Derived Bioactive Constituents Loaded in pH-ROS Dual-Responsive Polysaccharide Nanoparticles for Atherosclerosis Treatment
ジャーナル: Phytomedicine
DOI: 10.1016/j.phymed.2025.157536
IF: 8.3
アプリケーション: IF-tissue
交差反応性: Mouse
掲載日: 2025 Nov
-
A Novel Long-Term Intrathecal Cannulation Technique in Rats: L5-L6 Approach With Cervical Externalization for Chronic Drug Delivery
ジャーナル: Journal Of Integrative Neuroscience
DOI: 10.31083/JIN45111
IF: 2.7
アプリケーション: WB
交差反応性: Rat
掲載日: 2025 Nov
-
Targeting renal tubular WWP2 to restore mitochondrial OXPHOS integrity retards the AKI-to-CKD transition
ジャーナル: Molecular Therapy
DOI: 10.1016/j.ymthe.2025.11.022
IF: 12
アプリケーション: WB
交差反応性: Mouse
掲載日: 2025 Nov
-
Therapeutic potential of voltage-dependent potassium channel subtype 1.3 blockade in alleviating macrophage-related renal inflammation and fibrogenesis
ジャーナル: Cell Death Discovery
DOI: 10.1038/s41420-025-02508-7
IF: 6.1
アプリケーション: WB
交差反応性: Mouse,Human
掲載日: 2025 May
-
Podocyte FFAR4 deficiency aggravated glomerular diseases and aging
ジャーナル: Molecular Therapy
DOI: 10.1016/j.ymthe.2025.05.035
IF: 12.1
アプリケーション: IHC,WB
交差反応性: Mouse
掲載日: 2025 May
-
Discrepancies between human and murine model cerebral aneurysms at single-cell resolution
ジャーナル: Frontiers In Cell And Developmental Biology
DOI: 10.3389/fcell.2025.1512938
IF: 4.6
アプリケーション: mIHC
交差反応性: Human
掲載日: 2025 Mar
-
Vaccarin Ameliorates Renal Fibrosis by Inhibiting Ferroptosis via Nrf2/SLC7A11/GPX4 Signaling Pathway
ジャーナル: Drug Design Development And Therapy
DOI: 10.2147/DDDT.S509357
IF: 4.7
アプリケーション: WB
交差反応性: Mouse
掲載日: 2025 Mar
-
Chondroitin Sulfate-Based Imatinib Nanoparticles Targeting Activated Hepatic Stellate Cells Against Hepatic Fibrosis
ジャーナル: Pharmaceutics
DOI: 10.3390/pharmaceutics17030351
IF: 4.9
アプリケーション: WB
交差反応性: Rat
掲載日: 2025 Mar
-
Ultrasound-Driven Piezoelectric Heterostructures Block Early Atherosclerotic Plaques Progression
ジャーナル: Small
DOI: 10.1002/smll.202412815
IF: 12.1
アプリケーション: IF-Tissue
交差反応性: Mouse
掲載日: 2025 Mar
-
Preclinical and clinical evaluation of intratumoral injection of an IL-12 expressing SKV-012 oncolytic virus for advanced solid tumors
ジャーナル: Journal For Immunotherapy Of Cancer
DOI: 10.1136/jitc-2025-011642
IF: 10.6
アプリケーション: mIHC
交差反応性: Mouse
掲載日: 2025 Jun
-
Cardiomyocyte-derived YOD1 promotes pathological cardiac hypertrophy by deubiquitinating and stabilizing STAT3
ジャーナル: Science Advances
DOI: 10.1126/sciadv.adu8422
IF: 12.5
アプリケーション:
交差反応性:
掲載日: 2025 Jun
-
Tanshinone IIA attenuates hepatic stellate cell activation, oxidative stress, and liver fibrosis by inhibiting YAP signaling
ジャーナル: European Journal of Histochemistry
DOI: 10.4081/ejh.2025.4218
IF: 2.1
アプリケーション: WB
交差反応性: Human
掲載日: 2025 Jun
-
Pachymic acid alleviates secondary lymphedema through the modulation of EETs level and the inhibition of lymphatic fibrosis
ジャーナル: International Immunopharmacology
DOI: 10.1016/j.intimp.2025.115066
IF: 4.7
アプリケーション: IHC,WB
交差反応性: Mouse,Human
掲載日: 2025 Jun
-
Asprosin attenuates diabetic cardiomyopathy through inhibiting autophagy mediated by AMPK/mTOR/ULK1 pathway
ジャーナル: American Journal Of Physiology-Cell Physiology
DOI: 10.1152/ajpcell.01006.2024
IF: 4.7
アプリケーション: WB
交差反応性: Mouse,Rat
掲載日: 2025 Jun
-
Asiatic Acid Inhibits Keloid Fibroblast Migration and Collagen Deposition via Suppression of STAT3 Activation
ジャーナル: Burns
DOI: 10.1016/j.burns.2025.107586
IF: 2.9
アプリケーション: WB
交差反応性: Human
掲載日: 2025 Jun
-
PKM2 Drives Lactate-mediated Fibrosis in Liver Transplantation
ジャーナル: Transplantation
DOI: 10.1097/TP.0000000000005461
IF: 5
アプリケーション: IHC,FC,WB
交差反応性: Mouse
掲載日: 2025 Jun
-
Hepatic stellate cell-specific miR-214 expression alleviates liver fibrosis without boosting steatosis and inflammation
ジャーナル: Journal Of Translational Medicine
DOI: 10.1186/s12967-025-06880-x
IF: 7.5
アプリケーション: IHC
交差反応性: Mouse,Human
掲載日: 2025 Jul
-
Therapeutic Potential of PDA@CeO2 in Suppressing Hepatic Stellate Cell Activation and Preventing Liver Fibrosis
ジャーナル: International Journal Of Nanomedicine
DOI: 10.2147/IJN.S521372
IF: 6.5
アプリケーション: IHC,WB
交差反応性: Rat
掲載日: 2025 Jul
-
aPD-L1-facilitated theranostic and tumor microenvironment remodeling of pancreatic cancer via docetaxel-loaded phase-transformation nanoparticles triggered by low-intensity pulsed ultrasound
ジャーナル: Journal Of Nanobiotechnology
DOI:
IF: 10.6
アプリケーション: IF-cell
交差反応性: Mouse
掲載日: 2025 Jan
-
Inhibiting autophagy selectively prunes dysfunctional tumor vessels and optimizes the tumor immune microenvironment
ジャーナル: Theranostics
DOI: 10.7150/thno.98285
IF: 13.3
アプリケーション: mIHC
交差反応性: Mouse
掲載日: 2025 Jan
-
aPD-L1-facilitated theranostic and tumor microenvironment remodeling of pancreatic cancer via docetaxel-loaded phase-transformation nanoparticles triggered by low-intensity pulsed ultrasound
ジャーナル: JOURNAL OF NANOBIOTECHNOLOGY
DOI: 10.1186/s12951-025-03105-7
IF: 12.6
アプリケーション: IF-Tissue
交差反応性: Mouse
掲載日: 2025 Jan
-
Inhalable Chemotactic Liposome for Targeted Modulation of Pulmonary Pre-Metastatic Niche
ジャーナル: Advanced Functional Materials
DOI: 10.1002/adfm.202419583
IF: 19
アプリケーション: IF-Tissue
交差反応性: Mouse
掲載日: 2025 Jan
-
Integrated single-cell RNA sequencing reveals the tumor heterogeneity and microenvironment landscape during liver metastasis in adenocarcinoma of esophagogastric junction
ジャーナル: Frontiers In Immunology
DOI:
IF: 5.7
アプリケーション: IF-cell
交差反応性: Human
掲載日: 2025 Jan
-
Single-cell transcriptomic profiling of rat iridocorneal angle at perinatal stages: Revisiting the development of periocular mesenchyme
ジャーナル: Experimental Eye Research
DOI:
IF: 3
アプリケーション: IF-cell
交差反応性: Rat
掲載日: 2025 Jan
-
Magnetic Nanoactuator-Protein Fiber Coated Hydrogel Dressing for Well-Balanced Skin Wound Healing and Tissue Regeneration
ジャーナル: ACS Applied Nano Materials
DOI:
IF: 15.8
アプリケーション: WB
交差反応性: Mouse,Human
掲載日: 2025 Jan
-
Integrated single-cell RNA sequencing reveals the tumor heterogeneity and microenvironment landscape during liver metastasis in adenocarcinoma of esophagogastric junction
ジャーナル: Frontiers in Immunology
DOI: 10.3389/fimmu.2024.1484234
IF: 5.9
アプリケーション: IF-Tissue
交差反応性: Human
掲載日: 2025 Jan
-
Activation of the WNT4/ β-catenin/FOXO1 pathway by PDK1 promotes cervical cancer metastasis and EMT process
ジャーナル: JOURNAL OF MOLECULAR HISTOLOGY
DOI: 10.1007/s10735-024-10342-x
IF: 2.2
アプリケーション: WB
交差反応性: Human
掲載日: 2025 Jan
-
Hypoxia-inducible factor-1α inhibitor promotes non-alcoholic steatohepatitis development and increases hepatocellular lipid accumulation via TSKU upregulation
ジャーナル: Archives Of Biochemistry And Biophysics
DOI:
IF: 3.8
アプリケーション: WB
交差反応性: Mouse
掲載日: 2025 Jan
-
Liver-Secreted Extracellular Vesicles Promote Cirrhosis-Associated Skeletal Muscle Injury Through mtDNA-cGAS/STING Axis
ジャーナル: Advanced Science
DOI: 10.1002/advs.202410439
IF: 14.1
アプリケーション: WB
交差反応性: Mouse
掲載日: 2025 Jan
-
Hypoxia-inducible factor-1α inhibitor promotes non-alcoholic steatohepatitis development and increases hepatocellular lipid accumulation via TSKU upregulation
ジャーナル: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
DOI: 10.1016/j.abb.2025.110313
IF: 3
アプリケーション: WB
交差反応性: Mouse
掲載日: 2025 Jan
-
Safety, Efficacy and Bio-Distribution Analysis of Exosomes Derived From Human Umbilical Cord Mesenchymal Stem Cells for Effective Treatment of Bronchopulmonary Dysplasia by Intranasal Administration in Mice Model
ジャーナル: International Journal Of Nanomedicine
DOI: 10.2147/IJN.S501843
IF: 6.6
アプリケーション: IHC-P
交差反応性: Mouse
掲載日: 2025 Feb
-
FBXW7 mediates high glucose-induced epithelial to mesenchymal transition via KLF5 in renal tubular cells of diabetic kidney disease
ジャーナル: Tissue & Cell
DOI: 10.1016/j.tice.2025.102801
IF: 2.7
アプリケーション: WB
交差反応性: Human
掲載日: 2025 Feb
-
StatGel: An Innovative hydrogel carrying STAT3-targeted small molecule inhibitor for the treatment of abdominal adhesions
ジャーナル: International Journal Of Pharmaceutics
DOI: 10.1016/j.ijpharm.2025.125320
IF: 5.3
アプリケーション: IEM,WB
交差反応性: Mouse
掲載日: 2025 Feb
-
Distinct maturity and spatial distribution of tertiary lymphoid structures in head and neck squamous cell carcinoma: implications for tumor immunity and clinical outcomes
ジャーナル: Cancer Immunology Immunotherapy
DOI: 10.1007/s00262-025-03952-1
IF: 4.6
アプリケーション: mIHC
交差反応性: Human
掲載日: 2025 Feb
-
Vitamin D alleviates diabetic kidney damage via TREM2-dependent modulation of ferritinophagy and macrophage polarization
ジャーナル: International Immunopharmacology
DOI: 10.1016/j.intimp.2025.116076
IF: 4.7
アプリケーション: WB
交差反応性: Rat
掲載日: 2025 Dec
-
Rutaecarpine Alleviates Liver Fibrosis by Modulating the TRPV1/Connexin 43 Axis: A Study Based on Transcriptome Data, Single-cell Sequencing Data, and Cell Experiments
ジャーナル: Biochemical And Biophysical Research Communications
DOI: 10.1016/j.bbrc.2025.152506
IF: 2.2
アプリケーション: WB
交差反応性: Human
掲載日: 2025 Aug
-
Hesperetin alleviates liver fibrosis by improving intestinal microbiota composition and regulating hepatic stellate cell autophagy
ジャーナル: European Journal Of Pharmacology
DOI: 10.1016/j.ejphar.2025.178106
IF: 4.7
アプリケーション: WB,IHC
交差反応性: Mouse,Human
掲載日: 2025 Aug
-
Yanghe Pingchuan granules inhibit cellular senescence in airway smooth muscle cells to improve bronchial asthma via modulating Nrf2 acetylation
ジャーナル: Respiratory Research
DOI: 10.1186/s12931-025-03345-z
IF: 5
アプリケーション: IF-cell
交差反応性: Rat
掲載日: 2025 Aug
-
Renal tubular epithelial cell-derived Exosomal miR-330-3p plays a key role in fibroblast activation and renal fibrosis by regulating CREBBP
ジャーナル: Stem Cell Research & Therapy
DOI: 10.1186/s13287-025-04338-x
IF: 7.1
アプリケーション: IF-tissue
交差反応性: Mouse
掲載日: 2025 Apr
-
Cardiac protection of wogonin in mice with pulmonary fibrosis by regulating Sirt1/ γ-H2AX pathway
ジャーナル: Frontiers In Pharmacology
DOI: 10.3389/fphar.2025.1551141
IF: 4.4
アプリケーション: WB,IHC-P
交差反応性: Mouse
掲載日: 2025 Apr
-
Albiflorin inhibits inflammation to improve liver fibrosis by targeting the CXCL12/CXCR4 axis in mice
ジャーナル: Frontiers In Pharmacology
DOI: 10.3389/fphar.2025.1577201
IF: 4.4
アプリケーション: WB
交差反応性: Mouse
掲載日: 2025 Apr
-
Integrated bioinformatics analysis screened the key genes and pathways of idiopathic pulmonary fibrosis
ジャーナル: Scientific Reports
DOI: 10.1038/s41598-025-97037-9
IF: 3.8
アプリケーション: WB
交差反応性: Human
掲載日: 2025 Apr
-
Ferroptosis and Low-Grade Glioma: The Breakthrough Potential of NUAK2
ジャーナル: Free Radical Biology And Medicine
DOI: 10.1016/j.freeradbiomed.2025.04.035
IF: 7.1
アプリケーション: WB
交差反応性: Human
掲載日: 2025 Apr
-
Unconjugated bilirubin promotes uric acid restoration by activating hepatic AMPK pathway
ジャーナル: Free Radical Biology And Medicine
DOI: 10.1016/j.freeradbiomed.2024.09.023
IF: 7.1
アプリケーション: WB
交差反応性: Mouse
掲載日: 2024 Sept
-
A New Rat Model of Sacral Cord Injury Producing a Neurogenic Bladder and Its Functional and Mechanistic Studies
ジャーナル: Biomolecules
DOI:
IF: 4.8
アプリケーション: WB
交差反応性: Rat
掲載日: 2024 Sep
-
Tanshinone IIA alleviates liver fibrosis through inducing inactivation and ferroptosis in hepatic stellate cells
ジャーナル: Research Square
DOI:
IF:
アプリケーション: WB
交差反応性: Human
掲載日: 2024 Nov
-
Gut commensal Parabacteroides distasonis exerts neuroprotective effects in acute ischemic stroke with hyperuricemia via regulating gut microbiota-gut-brain axis
ジャーナル: Journal Of Translational Medicine
DOI:
IF: 6.1
アプリケーション: WB
交差反応性: Rat
掲載日: 2024 Nov
-
Transcriptomics of tissue exosomes to investigate miR-195-5p's amelioration of endometrial fibrosis via the YAP-Smad7 pathway: an animal study
ジャーナル: Journal Of Translational Medicine
DOI:
IF: 6.1
アプリケーション: IF-cell
交差反応性: Rat
掲載日: 2024 Nov
-
Nanomaterial‐Mediated Reprogramming of Macrophages to Inhibit Refractory Muscle Fibrosis
ジャーナル: Advanced Materials
DOI:
IF: 27.4
アプリケーション: IF-cell
交差反応性: Mouse
掲載日: 2024 Nov
-
Furin knockdown inhibited EndMT and abnormal proliferation and migration of endothelial cells
ジャーナル: Clinical Hemorheology And Microcirculation
DOI: 10.3233/CH-242171
IF: 2.1
アプリケーション: WB
交差反応性: Human
掲載日: 2024 May
-
Cell surface patching via CXCR4-targeted nanothreads for cancer metastasis inhibition
ジャーナル: Nature Communications
DOI:
IF: 16.6
アプリケーション: FC
交差反応性: Mouse
掲載日: 2024 Mar
-
Low-intensity pulsed ultrasound combined with ST36 modulate gastric smooth muscle contractile marker expression via RhoA/Rock and MALAT1/miR-449a/DLL1 signaling in diabetic rats
ジャーナル: Neurogastroenterology And Motility
DOI: 10.1111/nmo.14843
IF: 3.5
アプリケーション: WB
交差反応性: Rat
掲載日: 2024 Jun
-
Suppression of STK39 weakens the MASLD/MASH process by protecting the intestinal barrier
ジャーナル: Bioscience Trends
DOI:
IF: 5.7
アプリケーション: WB
交差反応性: Mouse
掲載日: 2024 Jul
-
Necroptosis plays a role in TL1A-induced airway inflammation and barrier damage in asthma
ジャーナル: Respiratory Research
DOI:
IF: 4.7
アプリケーション: WB
交差反応性: Human,Mouse
掲載日: 2024 Jul
-
Knockout of C1q/tumor necrosis factor-related protein-9 aggravates cardiac fibrosis in diabetic mice by regulating YAP-mediated autophagy
ジャーナル: Frontiers In Pharmacology
DOI: 10.3389/fphar.2024.1407883
IF: 4.4
アプリケーション: WB,IF-cell
交差反応性: Mouse
掲載日: 2024 Jul
-
circGRHPR inhibits aberrant epithelial-mesenchymal transformation progression of lung epithelial cells associated with idiopathic pulmonary fibrosis
ジャーナル: Cell Biology And Toxicology
DOI:
IF: 6.1
アプリケーション: WB
交差反応性: Human
掲載日: 2024 Jan
-
A Dual Role of Mesenchymal Stem Cell Derived Small Extracellular Vesicles on TRPC6 Protein and Mitochondria to Promote Diabetic Wound Healing
ジャーナル: ACS Applied Nano Materials
DOI: 10.1021/acsnano.3c09814
IF: 15.8
アプリケーション: WB
交差反応性: Rat
掲載日: 2024 Jan
-
miR-193b-5p promotes GCRV replication by inhibiting autophagy via targeting deptor in grass carp (Ctenopharyngodon idellus)
ジャーナル: Fish & Shellfish Immunology
DOI: 10.1016/j.fsi.2024.109453
IF: 4.1
アプリケーション: WB
交差反応性: Ctenopharyngodon
掲載日: 2024 Feb
-
Shen-Shuai-II-Recipe inhibits tubular inflammation by PPARα-mediated fatty acid oxidation to attenuate fibroblast activation in fibrotic kidneys
ジャーナル: Phytomedicine
DOI:
IF: 7.9
アプリケーション: WB
交差反応性: Rat
掲載日: 2024 Feb
-
Decoding the Cell Atlas and Inflammatory Features of Human Intracranial Aneurysm Wall by Single‐Cell RNA Sequencing
ジャーナル: Journal Of The American Heart Association
DOI: 10.1161/JAHA.123.032456
IF: 5
アプリケーション: IF-tissue
交差反応性: Human
掲載日: 2024 Feb
-
Niclosamide - encapsulated lipid nanoparticles for the reversal of pulmonary fibrosis
ジャーナル: Materials Today Bio
DOI:
IF: 8.7
アプリケーション: WB
交差反応性: Mouse
掲載日: 2024 Feb
-
A Novel Nanoscale Phase-Change Contrast Agent Evaluates the Hepatic Fibrosis Through Targeting Hepatic Stellate Cell Platelet-Derived Factor Beta Receptor by Ultrasound in Vitro
ジャーナル: Ultrasound In Medicine & Biology
DOI:
IF: 2.4
アプリケーション: IF-cell
交差反応性: Rat
掲載日: 2024 Dec
-
Salvianolic acid C promotes renal gluconeogenesis in fibrotic kidneys through PGC1α
ジャーナル: Biochemical And Biophysical Research Communications
DOI: 10.1016/j.bbrc.2024.151174
IF: 2.5
アプリケーション: WB
交差反応性: Mouse
掲載日: 2024 Dec
-
Tanshinone I improves renal fibrosis by promoting gluconeogenesis through upregulation of peroxisome proliferator-activated receptor-γ coactivator 1α
ジャーナル: Chronic Kidney Disease And Progression
DOI:
IF: 3
アプリケーション: WB
交差反応性: Human
掲載日: 2024 Dec
-
Targeted ultrasound-mediated molecular diagnosis and tumor microenvironment remodeling of pancreatic cancer with aPD-L1-modified docetaxel-loaded phase-transition nanoparticles
ジャーナル: Preprint And Has Not Been Certified By Peer Review
DOI:
IF:
アプリケーション: IF-cell
交差反応性: Mouse
掲載日: 2024 Aug
-
Lactobacillus-Polydopamine System for Targeted Drug Delivery in Overactive Bladder: Evidence from Bladder Cell Spheroids, Rat Models, and Urinary Microbiome Profiling
ジャーナル: International Journal Of Nanomedicine
DOI:
IF: 6.6
アプリケーション: IF-cell
交差反応性: Human
掲載日: 2024 Aug
-
The combination of paeoniflorin and metformin synergistically inhibits the progression of liver fibrosis in mice
ジャーナル: European Journal Of Pharmacology
DOI:
IF: 4.2
アプリケーション: WB,IHC-P
交差反応性: Mouse
掲載日: 2024 Aug
-
DIREN mitigates DSS-induced colitis in mice and attenuates collagen deposition via inhibiting the Wnt/β-catenin and focal adhesion pathways
ジャーナル: Biomedicine & Pharmacotherapy
DOI:
IF: 7.5
アプリケーション: IF-cell
交差反応性: Mouse
掲載日: 2024 Apr
-
CARD9 deficiency aggravated nonalcoholic steatohepatitis in mice through increasing inflammatory response
ジャーナル: Biochimica Et Biophysica Acta (Bba) - Molecular Basis Of Disease
DOI: 10.1016/j.bbadis.2023.166893
IF: 6.2
アプリケーション: WB
交差反応性: Mouse
掲載日: 2023 Sept
-
SDMA attenuates renal tubulointerstitial fibrosis through inhibition of STAT4
ジャーナル: Journal Of Translational Medicine
DOI:
IF: 8.440
アプリケーション: WB
交差反応性: Mouse
掲載日: 2023 May
-
The impact and mechanism of TET3 overexpression on the progression of hepatic fibrosis
ジャーナル: Epigenomics
DOI:
IF: 3.8
アプリケーション: WB
交差反応性: Mouse
掲載日: 2023 May
-
Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse
ジャーナル: Journal Of Applied Oral Science
DOI:
IF: 3.144
アプリケーション: IHC-P
交差反応性: Rat
掲載日: 2023 May
-
Shen Shuai II Recipe inhibits hypoxia-induced glycolysis by preserving mitochondrial dynamics to attenuate kidney fibrosis
ジャーナル: Journal Of Ethnopharmacology
DOI:
IF: 5.4
アプリケーション: WB
交差反応性: Rat
掲載日: 2023 May
-
Hypoxia Drives Material-Induced Heterotopic Bone Formation by Enhancing Osteoclastogenesis via M2/Lipid-Loaded Macrophage Axis
ジャーナル: Advanced Science
DOI:
IF:
アプリケーション: IF-tissue
交差反応性: Mouse
掲載日: 2023 May
-
TRIM21 deficiency protects against atrial inflammation and remodeling post myocardial infarction by attenuating oxidative stress
ジャーナル: Redox Biology
DOI:
IF: 11.4
アプリケーション: WB
交差反応性: Mouse
掲載日: 2023 Jun
-
Sodium houttuyfonate against cardiac fibrosis attenuates isoproterenol-induced heart failure by binding to MMP2 and p38
ジャーナル: Phytomedicine
DOI:
IF:
アプリケーション: WB
交差反応性: Mouse
掲載日: 2023 Jan
-
Long non-coding RNA MALAT1 sponges miR-30c to promote the calcification of human vascular smooth muscle cells by regulating Runx2
ジャーナル: Renal Failure
DOI:
IF: 3.222
アプリケーション: WB
交差反応性: Human
掲載日: 2023 Dec
-
Icariside II prevents kidney fibrosis development in chronic kidney disease by promoting fatty acid oxidation
ジャーナル: Phytotherapy Research
DOI: 10.1002/ptr.8085
IF: 7.2
アプリケーション: WB
交差反応性: Rat
掲載日: 2023 Dec
-
A cancer-associated fibroblast subtypes-based signature enables the evaluation of immunotherapy response and prognosis in bladder cancer
ジャーナル: iScience
DOI:
IF: 5.8
アプリケーション: IF-cell
交差反応性: Human
掲載日: 2023 Aug
-
ZNF32 prevents the activation of cancer‐associated fibroblasts through negative regulation of TGFB1 transcription in breast cancer
ジャーナル: FASEB Journal
DOI:
IF: 4.8
アプリケーション: WB
交差反応性: Mouse
掲載日: 2023 Apr
-
Hypoxia-Induced HIF-1α Expression Promotes Neurogenic Bladder Fibrosis via EMT and Pyroptosis
ジャーナル: Cells
DOI:
IF: 7.666
アプリケーション: WB
交差反応性: Rat
掲載日: 2022 Nov
-
The TL1A-DR3 Axis in Asthma: Membrane-Bound and Secreted TL1A Co-Determined the Development of Airway Remodeling
ジャーナル: Allergy Asthma & Immunology Research
DOI:
IF: 5.764
アプリケーション: WB
交差反応性: Human
掲載日: 2022 Mar
-
Loss of TRIM67 attenuates the progress of obesity-induced non-alcoholic fatty liver disease
ジャーナル: International Journal Of Molecular Sciences
DOI:
IF: 5.6
アプリケーション: WB,IHC-P
交差反応性: Mouse
掲載日: 2022 Jul
-
Natural Flavonoid Pectolinarigenin Alleviated Hyperuricemic Nephropathy via Suppressing TGFβ/SMAD3 and JAK2/STAT3 Signaling Pathways
ジャーナル: Frontiers In Pharmacology
DOI:
IF: 5.810
アプリケーション: WB,IHC-P
交差反応性: Mouse
掲載日: 2022 Jan
-
Shen Shuai Ⅱ Recipe attenuates renal fibrosis in chronic kidney disease by improving hypoxia-induced the imbalance of mitochondrial dynamics via PGC-1α activation
ジャーナル: Phytomedicine
DOI:
IF: 7.9
アプリケーション: WB
交差反応性: Human
掲載日: 2022 Jan
-
Discovery of indol-6-yl-pyrrolo[2,3-c]pyridin-7-one derivatives as bromodomain-containing protein 4 (BRD4) inhibitors for the treatment of kidney fibrosis
ジャーナル: European Journal Of Medicinal Chemistry
DOI: 10.1016/j.ejmech.2022.114153
IF: 7.088
アプリケーション: IHC-P
交差反応性: Mouse
掲載日: 2022 Feb
-
Salvianolic acid B attenuates tubulointerstitial fibrosis by inhibiting EZH2 to regulate the PTEN/Akt pathway
ジャーナル: Pharmaceutical Biology
DOI:
IF: 3.889
アプリケーション: WB
交差反応性: Mouse
掲載日: 2022 Dec
-
Follistatin-related protein 1 in asthma: miR-200b-3p interactions affect airway remodeling and inflammation phenotype
ジャーナル: International Immunopharmacology
DOI:
IF: 5.6
アプリケーション: WB
交差反応性: Human
掲載日: 2022 Aug
-
Gambogenic acid alleviates kidney fibrosis via epigenetic inhibition of EZH2 to regulate Smad7-dependent mechanism
ジャーナル: Phytomedicine
DOI: 10.1016/j.phymed.2022.154390
IF: 6.656
アプリケーション: IHC-P
交差反応性: Mouse
掲載日: 2022 Aug
-
Oxidative stress-mediated mitochondrial fission promotes hepatic stellate cell activation via stimulating oxidative phosphorylation
ジャーナル: Cell Death & Disease
DOI:
IF: 9.685
アプリケーション: IHC-P
交差反応性: Mouse
掲載日: 2022 Aug
-
Silencing of YAP attenuates pericyte-myofibroblast transition and subretinal fibrosis in experimental model of choroidal neovascularization
ジャーナル: Cell Biology International
DOI: 10.1002/cbin.11809
IF: 4.473
アプリケーション: WB
交差反応性: Human
掲載日: 2022 Apr
-
Inhibiting the Cytosolic Phospholipase A2–Arachidonic Acid Pathway With Arachidonyl Trifluoromethyl Ketone Attenuates Radiation-Induced Lung Fibrosis
ジャーナル: International Journal Of Radiation Oncology Biology Physics
DOI: 10.1016/j.ijrobp.2022.03.008
IF: 8.013
アプリケーション: IHC-P
交差反応性: Mouse
掲載日: 2022 Apr
-
Tanshinone I attenuates fibrosis in fibrotic kidneys through down-regulation of inhibin beta-A
ジャーナル: BMC Complementary Medicine and Therapies
DOI:
IF: 2.838
アプリケーション: WB
交差反応性: Mouse
掲載日: 2022 Apr
-
Fisetin Improves Hyperuricemia-Induced Chronic Kidney Disease via Regulating Gut Microbiota-Mediated Tryptophan Metabolism and Aryl Hydrocarbon Receptor Activation
ジャーナル: Journal Of Agricultural And Food Chemistry
DOI: 10.1021/acs.jafc.1c03449
IF: 5.279
アプリケーション: WB
交差反応性: Mouse
掲載日: 2021 Sept
-
Pharmacologic inhibiting STAT3 delays the progression of kidney fibrosis in hyperuricemia-induced chronic kidney disease
ジャーナル: Life Sciences
DOI: 10.1016/j.lfs.2021.119946
IF: 5.037
アプリケーション: WB
交差反応性: Mouse
掲載日: 2021 Sept
-
Icariin attenuates renal fibrosis in chronic kidney disease by inhibiting interleukin‐1β/transforming growth factor‐β‐mediated activation of renal fibroblasts
ジャーナル: Phytotherapy Research
DOI:
IF: 7.2
アプリケーション: WB
交差反応性: Rat
掲載日: 2021 Nov
-
TGF-β1-induced EMT activation via both Smad-dependent and MAPK signaling pathways in Cu-induced pulmonary fibrosis
ジャーナル: Toxicology And Applied Pharmacology
DOI:
IF: 4.211
アプリケーション: WB,IHC-P
交差反応性: Mouse
掲載日: 2021 May
-
Remdesivir Inhibits Tubulointerstitial Fibrosis in Obstructed Kidneys. Frontiers in pharmacology, 12, 626510.
ジャーナル: Frontiers In Pharmacology
DOI:
IF: 5.814
アプリケーション: WB
交差反応性: Rat
掲載日: 2021 Jul
-
Natural flavonol fisetin attenuated hyperuricemic nephropathy via inhibiting IL-6/JAK2/STAT3 and TGF-β/SMAD3 signaling. Phytomedicine : international journal of phytotherapy and phytopharmacology, 87, 153552.
ジャーナル: Phytomedicine
DOI:
IF: 4.268
アプリケーション: WB,IHC-P
交差反応性: Mouse
掲載日: 2021 Jul
-
METTL14-regulated PI3K/Akt signaling pathway via PTEN affects HDAC5-mediated epithelial–mesenchymal transition of renal tubular cells in diabetic kidney disease
ジャーナル: Cell Death & Disease
DOI:
IF: 8.462
アプリケーション: WB
交差反応性: Mouse
掲載日: 2021 Jan
-
Natural flavonoid pectolinarigenin alleviated kidney fibrosis via inhibiting the activation of TGFβ/SMAD3 and JAK2/STAT3 signaling. International immunopharmacology, 91, 107279.
ジャーナル: International Immunopharmacology
DOI:
IF: 3.94
アプリケーション: WB
交差反応性: Mouse
掲載日: 2021 Feb
-
Inhibition of Fatty Acid–Binding Protein 4 Attenuated Kidney Fibrosis by Mediating Macrophage-to-Myofibroblast Transition
ジャーナル: Frontiers In Immunology
DOI:
IF: 5.085
アプリケーション: WB
交差反応性: Human,Mouse
掲載日: 2020 Sep
-
Renal asymmetric dimethylarginine inhibits fibrosis
ジャーナル: Renal Adma And Fibrosis
DOI:
IF: 2.231
アプリケーション: WB
交差反応性: Mouse
掲載日: 2020 Oct
-
Pterostilbene, a bioactive component of blueberries, alleviates renal interstitial fibrosis by inhibiting macrophage-myofibroblast transition
ジャーナル: American Journal Of Chinese Medicine
DOI:
IF: 5.7
アプリケーション: WB
交差反応性: Mouse
掲載日: 2020 Nov
-
The pharmacodynamic and differential gene expression analysis of PPAR α/δ agonist GFT505 in CDAHFD-induced NASH model
ジャーナル: Public Library Of Science One
DOI:
IF: 2.74
アプリケーション: IHC-P
交差反応性: Mouse
掲載日: 2020 Dec
-
Reduced asymmetric dimethylarginine accumulation through inhibition of the type I protein arginine methyltransferases promotes renal fibrosis in obstructed kidneys.
ジャーナル: FASEB Journal
DOI:
IF: 5.391
アプリケーション: WB
交差反応性: Human
掲載日: 2019 Jun
-
Pterostilbene, a bioactive component of blueberries, alleviates renal fibrosis in a severe mouse model of hyperuricemic nephropathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 109, 1802–1808.
ジャーナル: Biomedicine & Pharmacotherapy
DOI:
IF: 3.457
アプリケーション: WB
交差反応性: Mouse
掲載日: 2019 Jan
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