SOX10 Recombinant Rabbit Monoclonal Antibody [SN20-41]
Catalog# ET1611-89
SOX10 Recombinant Rabbit Monoclonal Antibody [SN20-41]
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WB
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Human
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Mouse
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Rat
予測される交差反応性
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unconjugated
製品概要
製品名
SOX10 Recombinant Rabbit Monoclonal Antibody [SN20-41]
抗体のタイプ
Recombinant Rabbit monoclonal Antibody
免疫原
Synthetic peptide within Human SOX10 aa 400-450 / 466.
交差反応性（対応種属）
Human, Mouse (Predicted: Rat)
予測される交差反応性
検証済みアプリケーション
WB
標的分子量
Predicted band size: 50 kDa
ポジティブコントロール
SK-MEL-28 cell lysate, B16-F1 cell lysate, A375 cell lysate.
コンジュゲーション
unconjugated
クローン番号
SN20-41
RRID
製品の特徴
形態
Liquid
濃度
保存方法
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
保存バッファー
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
アイソタイプ
IgG
精製方法
Protein A affinity purified.
推奨希釈倍率
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WB
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1:5,000
ターゲット
機能
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
背景・参考文献
1. Pingault V et al. SOX10: 20 years of phenotypic plurality and current understanding of its developmental function. J Med Genet. 2022 Feb
2. Yoon EC et al. TRPS1, GATA3, and SOX10 expression in triple-negative breast carcinoma. Hum Pathol. 2022 Jul
組織特異性
Expressed in fetal brain and in adult brain, heart, small intestine and colon.
サブセルラー局在
Cytoplasm, Nucleus, Mitochondrion outer membrane.
別名
DOM antibody
DOM antibody
Dominant megacolon mouse human homolog of antibody
MGC15649 antibody
PCWH antibody
SOX 10 antibody
SOX10 antibody
SOX10_HUMAN antibody
SRY (sex determining region Y) box 10 antibody
SRY (sex determining region Y) box 10 antibody
詳細を見る画像
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Western blot analysis of SOX10 on different lysates with Rabbit anti-SOX10 antibody (ET1611-89) at 1/5,000 dilution.
Lane 1: SK-MEL-28 cell lysate
Lane 2: B16-F1 cell lysate
Lane 3: A375 cell lysate
Lysates/proteins at 15 µg/Lane.
Predicted band size: 50 kDa
Observed band size: 55/75 kDa
Exposure time: 5 minutes 10 seconds;
4-20% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (ET1611-89) at 1/5,000 dilution was used in 5% NFDM/TBST at 4℃ overnight. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1/50,000 dilution was used for 1 hour at room temperature.
ご注意: 本製品はすべて「研究用試薬」です。人や動物の診断・治療目的、または臨床診断には使用できません。（FOR RESEARCH USE ONLY）
同一ターゲット＆同一シグナル伝達経路の関連製品
SOX10 Recombinant Rabbit Monoclonal Antibody [PDH0-03]
Application: WB,IHC-P,IF-Cell,IF-Tissue,FC,IHC-Fr,IP
Reactivity: Human,Mouse,Rat,Cynomolgus monkey,Pig
Conjugate: unconjugated
SOX10 Recombinant Rabbit Monoclonal Antibody [PDH0-04]
Application: WB,IHC-P,IF-Cell,IF-Tissue,FC
Reactivity: Human,Mouse,Rat
Conjugate: unconjugated
SOX10 Recombinant Rabbit Monoclonal Antibody [PDH0-05]
Application: WB,IHC-P,IF-Cell,IF-Tissue,FC,IP
Reactivity: Human,Mouse,Rat
Conjugate: unconjugated
SOX10 Rabbit Polyclonal Antibody
Application: WB,IHC-P
Reactivity: Human,Mouse
Conjugate: unconjugated
