CD66b Rabbit Polyclonal Antibody
Catalog# IRS127RB
CD66b Rabbit Polyclonal Antibody
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mIHC
-
Human
-
unconjugated
製品概要
製品名
CD66b Rabbit Polyclonal Antibody
抗体のタイプ
Rabbit Polyclonal Antibody
免疫原
Recombinant protein within human CD66b aa 1-250.
交差反応性（対応種属）
Human
検証済みアプリケーション
mIHC
標的分子量
Predicted band size: 38 kDa
ポジティブコントロール
Human tonsil tissue.
コンジュゲーション
unconjugated
製品の特徴
形態
Liquid
濃度
保存方法
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
保存バッファー
1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.
アイソタイプ
IgG
精製方法
Immunogen affinity purified.
推奨希釈倍率
-
mIHC
-
1:100
ターゲット
機能
Carcinoembryonic antigen-related cell adhesion molecule 8, also designated CD67, CD66b or nonspecific cross-reacting antigen (NCA-95), belongs to the human carcinoembryonic antigen (CEA) family. The CD67 antigen is encoded by the CEACAM8 (CGM6) gene, which is exclusively expressed in neutrophils and eosinophils. In neutrophils, the CEACAM8 gene is primarily detected in the secondary granules within the cytoplasm, but it can also be found in lower amounts on the plasma membrane. The amount of CD67 on the plasma membrane is up-regulated upon granulocyte activation. CD67 has been located on the surface of neutrophilic and eosinophilic granulocytes at late stages of differentiation. It exhibits heterophilic cell adhesion properties with CD66c, which is coexpressed with CD67 in granulocytes. CD67, which is attached to the membrane by a GPI-anchor, is expressed in leukocytes of chronic myeloid leukemia patients and bone marrow and in granulocytes in the spleen, thymus and lungs.
背景・参考文献
1. Posabella A. et. al. High density of CD66b in primary high-grade ovarian cancer independently predicts response to chemotherapy. J Cancer Res Clin Oncol. 2020 Jan
2. Huang X. et. al. Prognostic significance of the infiltration of CD163(+) macrophages combined with CD66b(+) neutrophils in gastric cancer. Cancer Med. 2018 May
サブセルラー局在
Cell membrane, Cell surface.
UNIPROT #
別名
Carcinoembryonic antigen CGM6 antibody
Carcinoembryonic antigen gene family member 6 antibody
Carcinoembryonic antigen related cell adhesion molecule 8 antibody
Carcinoembryonic antigen-related cell adhesion molecule 8 antibody
CD 66b antibody
CD 67 antibody
CD66b antibody
CD66b antigen antibody
CD67 antibody
CD67 antigen antibody
詳細を見る画像
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mIHC analysis of human tonsil tissue (Formalin/PFA-fixed paraffin-embedded sections) with Rabbit anti-CD66b antibody (IRS127RB) at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900808). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
ご注意: 本製品はすべて「研究用試薬」です。人や動物の診断・治療目的、または臨床診断には使用できません。（FOR RESEARCH USE ONLY）
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