FOXP3 Recombinant Rabbit Monoclonal Antibody
Catalog# IRS008
FOXP3 Recombinant Rabbit Monoclonal Antibody
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mIHC
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Human
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unconjugated
製品概要
製品名
FOXP3 Recombinant Rabbit Monoclonal Antibody
抗体のタイプ
Recombinant Rabbit monoclonal Antibody
免疫原
Recombinant protein within human FOXP3 aa 101-370.
交差反応性（対応種属）
Human
検証済みアプリケーション
mIHC
標的分子量
Predicted band size: 47 kDa
ポジティブコントロール
Human lung cancer tissue, human tonsil tissue, human lung squamous cell carcinoma tissue.
コンジュゲーション
unconjugated
製品の特徴
形態
Liquid
濃度
保存方法
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
保存バッファー
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
アイソタイプ
IgG
精製方法
Protein A affinity purified.
推奨希釈倍率
-
mIHC
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1:100
ターゲット
機能
FOXP3 (forkhead box P3), also known as scurfin, is a protein involved in immune system responses. A member of the FOX protein family, FOXP3 appears to function as a master regulator of the regulatory pathway in the development and function of regulatory T cells. Regulatory T cells generally turn the immune response down. In cancer, an excess of regulatory T cell activity can prevent the immune system from destroying cancer cells. In autoimmune disease, a deficiency of regulatory T cell activity can allow other autoimmune cells to attack the body's own tissues.
背景・参考文献
1. Wang J et al. Human FOXP3 and tumour microenvironment. Immunology. 2023 Feb
2. Ziółkowska-Suchanek I et al. FOXP3: A Player of Immunogenetic Architecture in Lung Cancer. Genes (Basel). 2024 Apr
サブセルラー局在
Nucleus, Cytoplasm.
UNIPROT #
別名
AIID antibody
DIETER antibody
Forkhead box P3 antibody
Forkhead box protein P3 antibody
FOXP3 antibody
FOXP3_HUMAN antibody
FOXP3delta7 antibody
Immune dysregulation polyendocrinopathy enteropathy X linked antibody
Immunodeficiency polyendocrinopathy enteropathy X linked antibody
IPEX antibody
詳細を見る画像
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mIHC analysis of human lung cancer tissue (Formalin/PFA-fixed paraffin-embedded sections) with FOXP3 (IRS008), CD57 (IRS027), MPO (IRS037), CD8 (IRS007) and panCK (IRS010) antibody at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900802). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
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mIHC analysis of human tonsil tissue (Formalin/PFA-fixed paraffin-embedded sections) with Rabbit anti-FOXP3 antibody (IRS008) at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900808). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
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mIHC analysis of human lung squamous cell carcinoma tissue (Formalin/PFA-fixed paraffin-embedded sections) with Rabbit anti-FOXP3 antibody (IRS008) at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900808). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
ご注意: 本製品はすべて「研究用試薬」です。人や動物の診断・治療目的、または臨床診断には使用できません。（FOR RESEARCH USE ONLY）