Human LILRB4/ILT3, C-His, Flag Tag (ECD) Protein

見積もりを依頼する

お問い合わせ

E-mail: [email protected]

電話番号: 81-3-5684-1620

代理店・販売店を探す

Catalog# HA210719

Human LILRB4/ILT3, C-His, Flag Tag (ECD) Protein

Product Information

Product name

Human LILRB4/ILT3, C-His, Flag Tag (ECD) Protein

Catalog No.

HA210719

Predicted molecular mass

29 kD

Protein construction description

A DNA sequence encoding the human LILRB4/ILT3 protein (Q8NHJ6) (Gln 22-Glu 259) was expressed with both His and Flag tag at the C-terminus.

Accession

Q8NHJ6

Protein construction

LILRB4/ILT3 (22-259) His Flag

Source

HEK293

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance. Receptor for FN1. Receptor for apolipoprotein APOE. Receptor for ALCAM/CD166. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production. This inhibition of monocyte activation occurs at least in part via binding to FN1. Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells. Induces up-regulation of CD86 on dendritic cells. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation.

Usage guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.