Human BACE1, C-His Tag Protein

RMB: 900 特別割引 900

製品仕様

20μg

50μg

100μg

今すぐ注文，【现货】

問い合わせをクリック

お問い合わせ

メール: [email protected]

電話: 0571-88062880

代理店を調べる

Catalog# HA211177

Human BACE1, C-His Tag Protein

Product Information

Product name

Human BACE1, C-His Tag Protein

Catalog No.

HA211177

Predicted molecular mass

50.2 kD

Protein construction description

A DNA sequence encoding the human BACE1 protein (P56817-1) (Thr 22-Thr 457) was expressed with a His tag at the C-terminus.

Accession

P56817-1

Protein construction

BACE1 (22-457) His

Source

HEK293

Bio Activity

Testing in progress.

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

Beta-secretase 1, also known as beta-site amyloid precursor protein cleaving enzyme 1, beta-site APP cleaving enzyme 1 (BACE1), membrane-associated aspartic protease 2, memapsin-2, aspartyl protease 2, and ASP2, is an enzyme that in humans is encoded by the BACE1 gene. Expression of BACE1 is observed mainly in neurons. BACE1 is an aspartic acid protease important in the formation of myelin sheaths in peripheral nerve cells: in mice the expression of BACE1 is high in the postnatal stages, when myelination occurs. The transmembrane protein contains two active site aspartate residues in its extracellular protein domain and may function as a dimer, its cytoplasmic tail is required for the correct maturation and an efficient intracellular trafficking, but doesn't affect the activity. It is produced as a pro-enzyme, the endoproteolitc removal occurs after BACE leaves Endoplasmic reticulum, in the Golgi apparatus. In addition the pro-peptide receives additional sugars to increase the molecular mass. and the tail became a palmitoylated. The BACE1 expression is influenced by the inflammatory state: during AD the cytokines reduce the PPAR1 an inhibitor of BACE1 mRNA).

Usage guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water.

Human BACE1, C-His Tag Protein

RMB: 900 特別割引 900

製品仕様

お問い合わせ

Product Information

Product name

Catalog No.

Predicted molecular mass

Protein construction description

Accession

Protein construction

Source

Bio Activity

Purity

Endotoxin

Formulation

Species

Background

Usage guide

Shipping

Storage

Reconstitution

同じターゲット & 同じ経路の製品

Human S100A12,Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human alpha-Synuclein, C-His Tag Protein

Application:

Reactivity: Human

Conjugate:

Human SNAP25, Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human APP, C-His Tag (ECD) Protein

Application:

Reactivity: Human

Conjugate:

Human Cystatin C, C-His Tag Protein

Application:

Reactivity: Human

Conjugate:

Human Caspase-9/CASP9, Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human EPHA2, C-His Tag (ECD) Protein

Application:

Reactivity: Human

Conjugate:

Human Transthyretin/TTR, Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human Apolipoprotein E, Tag Free

Application:

Reactivity: Human

Conjugate:

Human TNF-alpha, Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human Beta-synuclein/SNCB, Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human PARK7/DJ-1, Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human Agrin, C-His Tag Protein

Application:

Reactivity: Human

Conjugate:

Human NPTX2, Tag Free Protein

Application:

Reactivity: Human

Conjugate:

Human UCH-L1/PGP9.5, Tag Free Protein