Glucagon Recombinant Rabbit Monoclonal Antibody

機能

Glucagon is a pancreatic hormone that functions as an antagonist to insulin, stimulating the conversion of glycogen to glucose and increasing blood sugar levels. Glucagon-like peptide-1 (GLP-1), Glucagon-like peptide-2 (GLP-2), VIP (vasoactive intestinal peptide) and PACAP (pituitary adenylate cyclase activating polypeptide) are members of the glucagon family of hormones. GLP-1 functions as a transmitter in the central nervous system, inhibiting feeding and drinking behavior, whereas GLP-2 is a stimulator of intestinal epithelial growth. VIP causes vasodilation resulting in the lowering of blood pressure. PACAP is abundant in the hypothalamus and has been shown to increase the synthesis of several hormones, including growth hormone.

背景・参考文献

1. Gao Z et al. Male Men1 heterozygous mice exhibit fasting hyperglycemia in the early stage of MEN1. J Endocrinol 230:347-55 (2016).

2. Long AJ et al. Syk Inhibition Induces Platelet Dependent Peri-islet Hemorrhage in the Rat Pancreas. Toxicol Pathol 44:998-1012 (2016).

サブセルラー局在

Secreted.

UNIPROT #

SwissProt: P01275 Human

別名

GCG antibody

glucagon