CD4 Rabbit Polyclonal Antibody

機能

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.

背景・参考文献

1. Parnes J R et al. L3T4 and the immunoglobulin gene superfamily: new relationships between the immune system and the nervous system. Immunol Rev 100:109-127 (1987).

2. Gorman S D et al. Structure of the mouse gene encoding CD4 and an unusual transcript in brain. Proc Natl Acad Sci USA 84:7644-7648 (1987).

3. Rudd CE. CD4,CD8 and the TCR-CD3 complex: a novel class of protein-tyrosine kinase receptor. Immunol Today 11(11):400-406 (1990).

組織特異性

Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells.

翻訳後修飾（PTM）

Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.; Phosphorylated by PKC; phosphorylation at Ser-433 plays an important role for CD4 internalization.

サブセルラー局在

Cell Membrane.

UNIPROT #

SwissProt: P01730 Human

別名