CD14 Rabbit Polyclonal Antibody

機能

CD14 is a glycophosphatidylinositol-anchored protein expressed on the surfaces of monocytes and plymorphonuclear leukocytes. It cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). CD14 acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response and up-regulates cell surface molecules, including adhesion molecules.

背景・参考文献

1. "Crystal structure of CD14 and its implications for lipopolysaccharide signaling."Kim J.I., Lee C.J., Jin M.S., Lee C.H., Paik S.G., Lee H., Lee J.O.J. Biol. Chem. 280:11347-11351(2005)

2. "The phagosomal proteome in interferon-gamma-activated macrophages."Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.Immunity 30:143-154(2009)

組織特異性

Detected on macrophages (at protein level). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.

翻訳後修飾（PTM）

N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.

サブセルラー局在

Cell membrane, Golgi apparatus , Secreted.

UNIPROT #

SwissProt: P08571 Human

SwissProt: P10810 Mouse

別名